"Good, the more communicated, more abundant grows. "
John Milton (1608-74); English poet.
Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood
Calculation and graphical interpretation of the acid-base and oxygen status of the blood
Contents
1. Textbook: Blood Oxygen and Acid-Base Status
Describes The Acid-Base Chart, The Oxygen Graph, The Blood Gas Map, and The Oxygen Consumption Diagram. Includes a List of Quantities and several Appendices. File: OsaTextbook.htm, 595 kB.
2. The Oxygen Status Algorithm
A computer program for calculation and graphical interpretation of the acid-base and oxygen status of the blood. The OSA program is a beta version. Start reading the Manual. File: OSA.exe, 822 kB. Version of 2005-09-18 with new temperature corrections for pH and pCO2.
3. About the Oxygen Status Algorithm
Requirements and limitations for using the Oxygen Status Algorithm. File: AboutOSA.htm, 11 kB.
4. Manual for the Oxygen Status Algorithm
How to use the OSA-program. File: OsaManual.htm, 74 kB.
5. Compiled HTML help file with Contents and Key Word Index
Compilation of all the above mentioned HTML files. Provides on-line help for using the OSA-program and for interpretation of the calculated acid-base and blood gas data. File: OSA.chm, 336 kB. This file should be in the same directory as osa.exe in order to provide on-line help. After OSA.chm is downloaded it may be necessary to right click the file, chose properties, and unblock.
6. Source code for calculations
The source code is written in Delphi 5. File: Unit_Calcul.pas, 33 kB. The complete source code for osa.exe may be available upon request.
Defines base excess as titratable hydrogen ion. Gives an annotated bibliography on Base Excess with comments on Strong Ion Difference. File: OsaAnthologyOnBE.htm, 45 kB.
8. FAQ related to the acid-base status of the blood New!
9. Bibliography
with full text for selected papers (PDF format)
FAQ
Which is the most relevant indicator of a "metabolic" acid-base disturbance, Base Excess or SID (Strong Ion Difference)?
Links
http://www.anaes.med.usyd.edu.au/lectures/acidbase_mjb/frameversion.html: Thorough and well written tutorial on acid-base physiology, by Michael Bookallil.
www.acid-base.com: A comprehensive description of the acid-base status of the blood, by Alan W. Grogono.
www.rcjournal.com/contents/01.99/01.99.026.asp: The strong ion difference approach: can a strong case be made for its use in acid base analysis? Editorial by eswenson@washington.edu.
www.anaesthetist.com/icu/elec/: The physicochemical approach to acid-base, the Stewart approach. By Jonathan Waters, Jaishen Rajah, and others.
http://acutecaretesting.org/: Sharing practical information about blood gas. Edited by Radiometer, Inc. Requires pass word.
2010.02.23
O.Siggaard-Andersen.
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